Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention
Authors' conclusion
Adipose tissue responds completely distinct from adaptations of skeletal muscle to exercise. The acute and repeated reduction in transcripts of lipid storage and lipogenesis, interconnected with a modulated circadian rhythm, can counteract metabolic syndrome progression toward diabetes.
Study context
- Population
- Sedentary participants (27 ± 4 yrs) with overweight or obesity; 8-week supervised endurance exercise 3×1h/week at 80% VO2peak8 female/6 male
- Participants
- 14 participants
- Comparison
- Subcutaneous adipose tissue (SCAT) vs skeletal muscle response to acute and repeated exercise
- Outcome
- Acutely regulated transcripts (FC > 1.2, FDR < 10%) after first exercise bout
- Follow-up
- 60 min after the first exercise bout
Methodological details8-week supervised endurance exercise intervention, matched transcriptomics of SCAT and skeletal muscle
- 8-week supervised endurance exercise intervention
- Matched transcriptomics of SCAT and skeletal muscle
Main finding
As reported in the abstract
- Transcripts regulated in both tissues
- 5
Original publication
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention. Int J Obes (Lond). Published 11 February 2023. doi:10.
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