Effects of Aerobic Training and Semaglutide Treatment on Pancreatic β-Cell Secretory Function in Patients With Type 2 Diabetes
Primary result · Insulin secretion (incremental AUC for insulin) during hyperglycemic clamp, with trainingResult — go to the resultMedian increase in total insulin secretion, difference 134 nM × 2 hours 95% CI 108–232Authors' conclusion
The combination of aerobic training and semaglutide treatment synergistically improved β-cell secretory function.
Study context
- Population
- Patients with T2D
- Participants
- 31 patients
- Comparison
- Aerobic training alone vs semaglutide treatment (20 weeks) followed by concurrent semaglutide and aerobic training
- Primary endpoint
- Change in insulin secretory capacity with training, by 2-stepped hyperglycemic (20 and 30 mM) clamp
- Follow-up
- 12 weeks of training
Primary result
As reported in the abstract
Insulin secretion (incremental AUC for insulin) during hyperglycemic clamp, with training · before vs after training
Median increase in total insulin secretion, difference
134 nM × 2 hours
95% CI 108–232
Semaglutide and trainingvs Training
median increase in total insulin secretion, difference 134 nM × 2 hours (95% CI 108–232)
- Training: insulin AUC, clamp step 1, 21 to 27 nM × 2 hours
- ratio 1.28, 95% CI 1.02-1.60
- Training: insulin AUC, clamp step 2, 40 to 64 nM × 2 hours
- ratio 1.61, 95% CI 1.25-2.07
- Semaglutide and training: insulin secretion, step 1, 130 to 171 nM × 2 hours
- ratio 1.31, 95% CI 1.06-1.63
- Semaglutide and training: insulin secretion, step 2, 525 to 697 nM × 2 hours
- ratio 1.33, 95% CI 1.02-1.72
Further findings
Insulin secretion with semaglutide treatment (before training) · 20 weeks of semaglutide
- Clamp step 1, 16 to 111 nM × 2 hours
- ratio 7.10, 95% CI 3.68-13.71
- Clamp step 2, 35 to 447 nM × 2 hours
- ratio 12.74, 95% CI 5.65-28.71
Original publication
Effects of Aerobic Training and Semaglutide Treatment on Pancreatic β-Cell Secretory Function in Patients With Type 2 Diabetes. J Clin Endocrinol Metab. Published 2 June 2023. doi:10.
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