Effects of a Low-Carbohydrate-High-Protein Pre-Exercise Meal in Type 1 Diabetes—a Randomized Crossover Trial
Authors' conclusion
Ingesting a LCHP pre-exercise meal lowered plasma glucose variability around exercise and diminished the drop in plasma glucose over exercise.
Study context
- Population
- Adults with insulin pump-treated T1D (11 women, 3 men); median HbA1c 50 mmol/mol (6.7%), age 49 years, BMI 24.0 kg/m²crossover
- Participants
- 14 adults
- Comparison
- Low-carbohydrate-high-protein (LCHP) vs high-carbohydrate-low-protein (HCLP) pre-exercise meal
Methodological detailsunblinded, 2-arm, Meal bolus dosed by meal carbohydrate content, reduced by 25%; basal rates reduced by 35% from meal to end of exercise
- Unblinded
- 2-arm
- Meal bolus dosed by meal carbohydrate content, reduced by 25%; basal rates reduced by 35% from meal to end of exercise
Primary result
As reported in the abstract
CV of glucose around exercise
P = 0.001
Further findings
Mean insulin concentration during exercise · 30% lower with LCHP
P < 0.001
| Outcome | LCHP | HCLP | P value |
|---|---|---|---|
| Change in glucose over exerciseLesser drop with LCHP | Δ-1.49 ± 1.89 mmol/L | Δ-3.78 ± 1.95 mmol/L | P = 0.001 |
Original publication
Effects of a Low-Carbohydrate-High-Protein Pre-Exercise Meal in Type 1 Diabetes—a Randomized Crossover Trial. J Clin Endocrinol Metab. Published 18 July 2023. doi:10.
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