Fat‐to‐muscle ratio is associated with insulin resistance and cardiometabolic disorders in adults with type 1 diabetes mellitus
Authors' conclusion
FMR is associated with IR and CMD in adults with T1DM and could be used as a promising parameter for targeting treatment in T1DM.
Study context
- Population
- Adults with T1D; 52.6% men, median age 32.4 (24.5, 43.0) years; body composition by bioelectrical impedance analysis
- Participants
- 420 adults
- Exposure
- Fat-to-muscle ratio (FMR) tertile 3 vs tertile 1
- Outcome
- Association of FMR tertiles with insulin resistance (IR) and cardiometabolic disorders (CMD)
Main finding
As reported in the abstract
Estimate (95% CI)
FMR tertile 3vs FMR tertile 1
multivariable-adjusted OR (IR, men) 4.8(1.9–12.1)
FMR tertile 3vs FMR tertile 1
multivariable-adjusted OR (CMD, men) 9.7(4.2–22.3)
FMR tertile 3vs FMR tertile 1
multivariable-adjusted OR (IR, women) 4.0(1.2–12.9)
FMR tertile 3vs FMR tertile 1
multivariable-adjusted OR (CMD, women) 5.8(2.4–13.6)
Observational data: associations, not effects.
Further findings
| Outcome | Men | Women | P value |
|---|---|---|---|
| FMR by sex | 0.39 (IQR 0.31–0.53) | 0.74 (IQR 0.63–0.92) | P < 0.001 |
Prevalence of insulin resistance (IR) and cardiometabolic disorders (CMD) (all participants)
- Prevalence of IR
- 18%
- Prevalence of CMD
- 38.6%
HbA1c (all participants)
- Median HbA1c
- 7.4 (6.5, 8.7)%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Fat‐to‐muscle ratio is associated with insulin resistance and cardiometabolic disorders in adults with type 1 diabetes mellitus. Diabetes Obes Metab. Published 17 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →