Effects of body weight variability on risks of macro- and microvascular outcomes in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort
Authors' conclusion
Increased BWV was associated with most adverse outcomes; however, in those who were physically-active or consistently losing weight, it was not hazardous and might be even beneficial.
Study context
- Population
- Individuals with T2D, Rio de Janeiro type 2 diabetes cohort
- Participants
- 684 individuals
- Exposure
- Increased vs lower body weight variability
- Outcome
- Macro- and microvascular outcomes: total cardiovascular events, MACE, cardiovascular deaths, all-cause mortality and microvascular outcomes
- Follow-up
- Median 11 years
Methodological detailsmultivariable Cox regression, interaction/subgroup analyses
- Multivariable Cox regression
- Interaction/subgroup analyses
Main finding
As reported in the abstract
Macro- and microvascular outcomes by BWV
- Total cardiovascular events
- 194
- MACE
- 174
- All-cause deaths
- 223
- Cardiovascular deaths
- 110
- Renal development/worsening outcomes
- 215
- Retinopathy development/worsening outcomes
- 152
- Peripheral neuropathy development/worsening outcomes
- 167
Observational data: associations, not effects.
Further findings
Subgroups: physical activity and weight loss ≥5%
- Increased body weight variability (BWV) associated with higher risks of outcomes in sedentary individuals and in those who did not lose ≥5% of body weight
- In physically-active participants or those who lost ≥5% weight, adjusted risks were null or protective
Original publication
Effects of body weight variability on risks of macro- and microvascular outcomes in individuals with type 2 diabetes: The Rio de Janeiro type 2 diabetes cohort. Diabetes Res Clin Pract. Published 3 November 2023. doi:10.
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