Effectiveness of Continuous Glucose Monitoring on Metrics of Glycemic Control in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors' conclusion
Both rt-CGM and flash CGM led to modest but statistically significant declines in HbA1c among individuals with T2DM, with little heterogeneity in the results. However, the duration of the included RCTs was relatively short and few studies reported on important clinical outcomes, such as adverse events, emergency department use, or hospitalization. Longer term studies are needed to determine if the short-term improvements in glucose control leads to improvements in clinically important outcomes.
Study context
- Population
- Adults (≥18 years) with T2D; Randomized controlled trials (RCTs) from MEDLINE, Embase and Cochrane14 RCTs
- Comparison
- CGM vs self-monitored blood glucose
- Real-time CGM (rt-CGM)n = 825
- FGMn = 822
- Outcome
- HbA1c reduction with CGM
Methodological detailsGRADE certainty assessment
- GRADE certainty assessment
Pooled result
As reported in the abstract
Modest but statistically significant hemoglobin A1c (HbA1c) reduction with CGM (moderate certainty)
about 0.32%
Further pooled results
HbA1c reduction by device type
- HbA1c reduction with rt-CGM
- 0.34%
- HbA1c reduction with FGM
- 0.33%
Other glucose metrics
- Trends for improvement in other glucose metrics favoring rt-CGM over SMBG
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →