Effects of glucagon‐like peptide‐1 receptor agonists on glycated haemoglobin and continuous glucose monitoring metrics as adjunctive therapy to insulin in adults with type 1 diabetes: A meta‐analysis of randomized controlled trials
Pooled result · HbA1cResult — go to the resultMD −0.21 % 95% CI −0.36 to −0.06Authors' conclusion
Our findings suggest that, in individuals with T1D, add-on therapy with GLP-1RAs does not confer significant benefits in terms of CGM metrics and is associated with a longer time below the target glycaemic range.
Study context
- Population
- Adults with T1D on insulin therapy; Randomized controlled trials (RCTs) from Medline, Cochrane Library and Google Scholar up to 27 May 2024
- Participants
- 378 adults6 RCTs
- Comparison
- GLP-1 RA add-on to insulin vs placebo
- Outcome
- HbA1c
Methodological detailsrandom-effects meta-analysis, dual-independent study selection, data extraction and quality assessment
- Random-effects meta-analysis
- Dual-independent study selection, data extraction and quality assessment
Pooled result
As reported in the abstract
MD
−0.21 %
95% CI −0.36 to −0.06
P = 0.007
GLP-1RAsvs Placebo
MD −0.21 % (95% CI −0.36 to −0.06); P = 0.007
Further pooled results
| Outcome | MD (%) (95% CI) | P value | |
|---|---|---|---|
| TIRSimilar TIR | −0.22 (−2.39 to 1.95) | P = 0.84 | |
| TAR | −1.83 (−2.51 to −1.15) | P < 0.001 | |
| −4−202Difference, % (linear scale) |
Other secondary outcomes (MAGE, CONGA-60 min, mean daily glucose, CV, mean SD of weekly glucose)
- Nonsignificant differences
Safety
| Outcome | MD (%) (95% CI) | P value | |
|---|---|---|---|
| TBR | 1.13 (0.50–1.76) | P < 0.001 | |
| −1012Difference, % (linear scale) |
Original publication
Effects of glucagon‐like peptide‐1 receptor agonists on glycated haemoglobin and continuous glucose monitoring metrics as adjunctive therapy to insulin in adults with type 1 diabetes: A meta‐analysis of randomized controlled trials. Diabetes Obes Metab. Published 30 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →