Effect of onset of type 2 diabetes on risks of cardiovascular disease and heart failure among new Zealanders with impaired glucose tolerance over 25 years: tapered-matched landmark analysis
Authors' conclusion
The study suggests that the diagnosis of T2D mediates the risk of CVD and HF in people with IGT. The development of risk scores to identify and better manage individuals with IGT at high risk of T2D is warranted.
Study context
- Population
- Patients with IGT identified in primary care in South and West Auckland, New Zealand (NZ), 1994–2019enrolled with IGT
- Participants
- 26,794 patients
- Exposure
- Onset of T2D vs no T2D within 5 years in people with IGT
- T2Dn = 845
- No T2Dn = 15,452reference
- Outcome
- Risk of CVD and HF
- Follow-up
- 5 and 10 years
Methodological detailstapered matching, landmark analysis
- Tapered matching
- Landmark analysis
Main finding
As reported in the abstract
T2D vs No T2DHazard ratio (95% CI)
5-year CVD; similar risk
1.19(0.61–2.32)
10-year CVD
2.45(1.40–4.29)
5-year HF
1.94(1.20–3.12)
10-year HF
2.84(1.83–4.39)
Observational data: associations, not effects.
Further findings
Subgroups
- Association with 10-year CVD and 5- and 10-year HF more likely among men, socioeconomically deprived, current smokers, those with higher metabolic measures and/or lower renal function
- NZ European ethnicity had lower 10-year CVD risk
Original publication
Effect of onset of type 2 diabetes on risks of cardiovascular disease and heart failure among new Zealanders with impaired glucose tolerance over 25 years: tapered-matched landmark analysis. Cardiovasc Diabetol. Published 30 June 2023. doi:10.
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