Effect of Waiting Time for Radioactive Iodine Therapy on Outcome in N1 Stage Papillary Thyroid Cancer
An erratum to this article was published (J Clin Endocrinol Metab, 17 Mar 2025 ↗)
Main finding · Disease persistence/recurrenceResult — go to the resultOdds ratio 2.47 95% CI 1.60–3.82Authors' conclusion
Delayed RAIT beyond 88 days after TT in patients with N1 PTC independently increased the risk of disease persistence/recurrence. Evaluation of the predictive determinants of prolonged WRAIT may help target at-risk patients and facilitate interventions.
Study context
- Population
- Patients with N1 PTC referred for radioactive iodine therapy (RAIT) after total thyroidectomy, 2014–2018, university hospital
- Participants
- 909 patients
- Exposure
- Delayed RAIT vs early RAIT after total thyroidectomy
- Delayed RAITn = 464
- Outcome
- Tumor persistence/recurrence
Methodological detailssingle university hospital, inverse probability weighting based on propensity score
- Single university hospital
- Inverse probability weighting based on propensity score
Main finding
Disease persistence/recurrence
Odds ratio
2.47
95% CI 1.60–3.82
Delayed RAITvs Early RAIT
OR 2.47 (95% CI 1.60–3.82)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Predictors of delayed RAIT
- Residence in lower-income areas, reoperation before initial RAIT, total thyroidectomy (TT) at a nonuniversity-affiliated hospital, multifocality, extrathyroidal extension, N1b disease, and pre-RAIT-stimulated Tg <1 ng/mL
Original publication
Effect of Waiting Time for Radioactive Iodine Therapy on Outcome in N1 Stage Papillary Thyroid Cancer. J Clin Endocrinol Metab. Published 11 May 2023. doi:10.
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