Effect of pulmonary function on bone mineral density in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2010 study
Authors' conclusion
Our study shows that PF is positively associated with BMD in the US population. A variety of factors such as race and age influence this relationship. the relationship between PF and BMD needs to be further investigated, including specific regulatory mechanisms and confounding factors.
Study context
- Population
- US NHANES subjects 2007–2010; mean age 44.51 ± 15.64 years; total femur bone mineral density (BMD) by DXA
- Participants
- 6,327 subjects
- Outcome
- Association between pulmonary function (PF) (FEV1 % predicted, FEV1/FVC) and BMD
Methodological detailsNHANES 2007–2010, multiple linear regression, adjusted for confounders
- NHANES 2007–2010
- Multiple linear regression, adjusted for confounders
Main finding
As reported in the abstract
FEV1 (% predicted) and femur BMD
Positive correlation, adjusted for race, age, alcohol, body mass index (BMI), height, poor income ratio (PIR), total protein, serum calcium, uric acid, cholesterol, phosphorus, blood urea nitrogen
β 0.032
95% CI 0.010–0.054P = 0.004
Observational data: associations, not effects.
Further findings
FEV1/FVC and spine BMD
- Positive correlation
- β 0.275 (95% CI 0.102-0.448, P = 0.002)
Original publication
Effect of pulmonary function on bone mineral density in the United States: results from the NHANES 2007–2010 study. Osteoporos Int. Published 23 March 2023. doi:10.
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