Micronutrient Supplementation and Bone Health After Prophylactic Total Gastrectomy in Patients With CDH1 Variants
Authors' conclusion
Appropriate micronutrient supplementation and nutritional counseling pre- and postoperatively in patients undergoing prophylactic TG are important to mitigate the long-term effects of gastrectomy on bone health.
Study context
- Population
- Patients with germline CDH1 variants who underwent prophylactic total gastrectomy (TG), October 2017–February 2022
- Participants
- 94 patients
- Exposure
- Pre- vs post-gastrectomy; adherence vs nonadherence to calcium and multivitamin supplementation
- Outcome
- BMD after TG
- Follow-up
- 12 months post-TG
Main finding
As reported in the abstract
- Average bone mineral density (BMD) decreased in all patients
- Nonadherence to calcium supplementation associated with decrease in BMD
- Nonadherence to multivitamin supplementation associated with greater percent BMD loss in femoral neck and total hip
Observational data: associations, not effects.
Further findings
Weight loss post-TG · 12 months post-surgery
- Patients who lost a substantial amount of weight
- 92/94, 98%
- Average weight loss
- 26.5%
Serum calcium and phosphorus
- Did not change significantly after TG
Original publication
Micronutrient Supplementation and Bone Health After Prophylactic Total Gastrectomy in Patients With CDH1 Variants. J Clin Endocrinol Metab. Published 23 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →