Effect of postoperative radiotherapy for patients with differentiated thyroid cancer
Authors' conclusion
PORT reduced locoregional recurrence in DTC patients without severe toxicity. PORT can be an effective and safe treatment to improve locoregional control in DTC with high risk features. However, further study is warranted to identify those who can benefit from PORT.
Study context
- Population
- Patients treated for differentiated thyroid cancer (DTC) with high risk features (pT4 or pN1b, poorly differentiated thyroid cancer (PDTC), or unfavourable variants such as anaplastic foci) or who received postoperative radiotherapy (PORT), 1985–2019108 matched analysed
- Participants
- 187 patients
- Exposure
- PORT vs No PORT
- Outcome
- Locoregional recurrence free survival (LRFS)
- Follow-up
- 5 years
Methodological details1:1 propensity matching, Median follow-up of matched group 10.4 years, After matching, PORT group still had more PDTC and DTC with anaplastic foci; Radioactive iodine (RAI) less frequently given with PORT
- 1:1 propensity matching
- Median follow-up of matched group 10.4 years
- After matching, PORT group still had more PDTC and DTC with anaplastic foci; RAI less frequently given with PORT
Main finding
As reported in the abstract
Hazard ratio
0.3
95% CI 0.1–0.8
P = 0.02
By group
Observational data: associations, not effects.
Further findings
CSS · 10 years · similar
P = 0.122
Cancer specific survival (CSS) · 10 years
- PORT not a favourable prognostic factor for CSS in multivariable analysis
Salvage surgery followed by salvage PORT among patients without PORT for initial disease
- Received salvage surgery + salvage PORT
- 39 of 133
Safety
- No severe toxicity after PORT reported
Original publication
Effect of postoperative radiotherapy for patients with differentiated thyroid cancer. Clin Endocrinol (Oxf). Published 30 December 2022. doi:10.
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