Effect of metformin on central arterial stiffness in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis
Pooled result · PWVResult — go to the resultPooled MD 0.09 m/s 95 % CI −0.06 to 0.25Authors' conclusion
In conclusion, metformin does not significantly affect PWV but is linked to a modest increase in cSBP
Study context
- Population
- Individuals with T2D
- Comparison
- Metformin vs comparison groups
- Outcome
- Central arterial stiffness: Pulse wave velocity (PWV)
Methodological detailsPooled analyses in RevMan, Searches of PubMed/MEDLINE, ScienceDirect, Cochrane and Google Scholar, Data extraction and quality assessment by three independent reviewers
- Pooled analyses in RevMan
- Searches of PubMed/MEDLINE, ScienceDirect, Cochrane and Google Scholar
- Data extraction and quality assessment by three independent reviewers
Pooled result
PWV
Pooled MD
0.09 m/s
95 % CI −0.06 to 0.25
P = 0.23
By group
Metformin
8.9-11.2
m/s
Comparison
8.0-11.8
m/s
Metforminvs Comparison
pooled MD 0.09 m/s (95 % CI −0.06 to 0.25); P = 0.23
As reported in the abstract
Further pooled results
| Outcome | MD (mmHg) (95 % CI) | P value | |
|---|---|---|---|
| Central systolic blood pressure (cSBP)I2 = 0 % | 3.30 (0.60–6.00) | P = 0.02 | |
| −50510Difference, mmHg (linear scale) |
Original publication
Effect of metformin on central arterial stiffness in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetes Res Clin Pract. Published 14 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →