Association of arterial stiffness and neuropathy in diabetes: a systematic review and meta-analysis
Authors' conclusion
Increased arterial stiffness is associated with CAN and PN.
Study context
- Population
- Observational studies of arterial stiffness and neuropathy (cardiac autonomic neuropathy (CAN), peripheral neuropathy (PN)), 59 of 60 including people with diabetes; Medline and Embase60 studies
- Comparison
- Neuropathy vs no neuropathy
- Outcome
- Arterial stiffness (pulse wave velocity (PWV), pulse pressure, augmentation index) by neuropathy status
Pooled result
As reported in the abstract
Arterial stiffness in CAN (19 studies)
Neuropathy vs No neuropathyMD, m/s (95% CI)P value
PWV; higher with neuropathy
1.32(0.82–1.81)
P < 0.00001Neuropathy vs No neuropathyMD, mmHg (95% CI)P value
Pulse pressure; higher with neuropathy
6.25(4.51–7.99)
P < 0.00001Neuropathy vs No neuropathyMD, % (95% CI)P value
Augmentation index; higher with neuropathy
5.52(3.46–7.58)
P < 0.0001Further pooled results
| Outcome | MD (m/s) (95% CI) | P value | |
|---|---|---|---|
| Arterial stiffness in PN (26 studies)Neuropathyvs No neuropathyPWV; higher with neuropathy | 1.22 (0.87–1.58) | P < 0.00001 | |
| −1012Difference, m/s (linear scale) |
| Outcome | MD (mmHg) (95% CI) | P value | |
|---|---|---|---|
| Arterial stiffness in PN (26 studies)Neuropathyvs No neuropathyPulse pressure; higher with neuropathy | 4.59 (2.96–6.22) | P < 0.00001 | |
| −50510Difference, mmHg (linear scale) |
Temporality
- Only two cohort studies located; temporality of the association remains unclear
Original publication
Association of arterial stiffness and neuropathy in diabetes: a systematic review and meta-analysis. BMJ Open Diabetes Res Care. Published 6 February 2023. doi:10.
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