Determinants of Orthostatic Hypotension in Type 2 Diabetes: Is Cardiac Autonomic Neuropathy the Main Factor?
Authors' conclusion
CAN remains the primary determinant of OH in T2D but does not explain all its variance. The index ΔHR/ΔSBP may represent a useful clinical tool to identify neurogenic OH.
Study context
- Population
- Participants with T2D assessed for orthostatic hypotension (OH) and cardiovascular autonomic neuropathy (CAN) by HR-based cardiovascular reflex tests (HR-CARTs)
- Participants
- 208 participants
- Outcome
- Determinants of orthostatic hypotension (OH) in T2D
Main finding
As reported in the abstract
Determinants of OH (multiple logistic regression)
- OH present
- 25 participants
- HR-CAN, main determinant of OH (OR)
- 4.74
- Physical activity (OR)
- 0.16
- Hypertension (OR)
- 0.23
- Model R2
- 0.22
Observational data: associations, not effects.
Further findings
Diagnostic accuracy of ΔHR/ΔSBP for neurogenic OH (OH plus confirmed HR-CAN)
- AUC
- 0.816 ± 0.087
- Sensitivity at cutoff 0.5 bpm/mm Hg
- 100%
- Specificity at cutoff 0.5 bpm/mm Hg
- 63.2%
Original publication
Determinants of Orthostatic Hypotension in Type 2 Diabetes: Is Cardiac Autonomic Neuropathy the Main Factor? Endocr Pract. Published 20 June 2024. doi:10.
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