Elevated serum hemoglobin A1c (HbA1c) level, rather than previous history of diabetes, predicts the disease severity and clinical outcomes of acute pancreatitis
Authors' conclusion
Generally known, diabetes is closely related to the development of AP, and strict control of blood glucose can improve the related complications. Thus, the level of glycemic control before the onset of AP (HbA1c as an indicator) is the key to poor prognosis of AP, rather than basic history of diabetes. Elevated serum HbA1c level can become the potential indicator for predicting the disease severity of AP.
Study context
- Population
- Patients with acute pancreatitis (AP), January 2013 to December 2020
- Participants
- 441 patients
- Exposure
- High vs normal serum HbA1c
- H-HbA1cn = 194
- N-HbA1cn = 247reference
- Outcome
- Disease severity and organ failure (OF)
Main finding
As reported in the abstract
Best HbA1c cut-off for predicting organ failure (OF)
7.05%
AUC for predicting OF
0.79
Observational data: associations, not effects.
Further findings
AP severity by diabetes history
- Diabetes history with HbA1c <6.5%: severity significantly lower than H-HbA1c
- No significant difference between with and without diabetes history in N-HbA1c
Original publication
Elevated serum HbA1c level, rather than previous history of diabetes, predicts the disease severity and clinical outcomes of acute pancreatitis. BMJ Open Diabetes Res Care. Published 6 February 2023. doi:10.
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