Effect of Inactivated and mRNA COVID-19 Vaccination on Thyroid Function Among Patients Treated for Hyperthyroidism
Authors' conclusion
Among patients treated for hyperthyroidism, abnormal thyroid function was a factor predicting unvaccinated status. Our results should encourage patients treated for hyperthyroidism to receive COVID-19 vaccination to protect themselves from adverse outcomes and potential long-term sequelae of COVID-19.
Study context
- Population
- Consecutive patients treated for hyperthyroidism at a teaching-hospital thyroid clinic, Jan–Sep 2021; mean age 51.6 years, 82.1% female, 86.2% GD67.3% vaccinated
- Participants
- 910 patients
- Exposure
- COVID-19 vaccination vs no vaccination
- Outcome
- Thyroid function instability (worsening of thyroid function/increase in antithyroid drug dosage)
- Follow-up
- Median 5.3 months
Methodological detailsconsecutive patients, single-centre
- Consecutive patients
- Single-centre
Main finding
As reported in the abstract
Thyroid function instability, all patients
15.9%
COVID-19 vaccination did not increase risks of thyroid function instability: HR
0.78
95% CI 0.56–1.09P = .151
Observational data: associations, not effects.
Further findings
Factors associated with unvaccinated status
- Abnormal thyroid function and cardiovascular comorbidities independently associated with unvaccinated status
Safety
Vaccination while overtly thyrotoxic
- Overtly thyrotoxic patients vaccinated without thyroid storm or difficulty in subsequent thyroid function control
- 27
Original publication
Effect of Inactivated and mRNA COVID-19 Vaccination on Thyroid Function Among Patients Treated for Hyperthyroidism. J Clin Endocrinol Metab. Published 1 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →