Effect of behavioral weight‐loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial
Authors' conclusion
All intervention groups prompted a notable beneficial change among biomarkers of insulin resistance and cardiometabolic health. However, the addition of at least moderate-intensity physical activity to a diet-only intervention did not provide any additional benefit. These findings highlight that an average weight loss of approximately 10% profoundly impacts biomarkers of insulin resistance and cardiometabolic disease in adults with overweight or obesity.
Study context
- Population
- Adults with overweight or obesity in a 12-month behavioral weight-loss intervention
- Participants
- 374 adults
- Comparison
- Diet alone vs diet plus 150 or 250 min/wk moderate-intensity physical activity
- Primary endpoint
- Change in novel biomarkers of cardiometabolic health (NMR spectroscopy)
- Follow-up
- 12 months
Primary result
As reported in the abstract
Body weight, Lipoprotein Insulin Resistance Index, Diabetes Risk Index, branched-chain amino acids, GlycA
- All groups significantly improved body weight
- time: p < 0.0001
- All groups significantly improved Lipoprotein Insulin Resistance Index score
- time: p < 0.0001
- All groups significantly improved Diabetes Risk Index score
- time: p < 0.0001
- All groups significantly improved branched-chain amino acid concentration
- time: p < 0.0001
- All groups significantly improved GlycA concentration
- time: p < 0.0001
Original publication
Effect of behavioral weight‐loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial. Obesity (Silver Spring). Published 9 January 2023. doi:10.
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