Effect of a high‐protein and low‐glycaemic index diet during pregnancy in women with overweight or obesity on offspring metabolic health—A randomized controlled trial
Authors' conclusion
An HPLGI diet during pregnancy may lead to adverse metabolic outcomes in the offspring, necessitating further investigation into long-term health implications.
Study context
- Population
- Offspring of pregnant women with pre-pregnancy BMI 28–45 kg/m²
- Participants
- 208 offspring
- Comparison
- High-protein and low-glycaemic-index (HPLGI) diet vs moderate-protein moderate-glycaemic-index (MPMGI) diet during pregnancy
- Primary endpoint
- Offspring body composition and metabolic health
- Follow-up
- Birth to 5 years of age
Methodological detailsdietary intervention, offspring follow-up from birth to 5 years
- Dietary intervention
- Offspring follow-up from birth to 5 years
Primary result
As reported in the abstract
BMI z-scores · different ages
- No differences in BMI z-scores at different ages
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Glucose · birth | difference 0.43 mmol/L | P = 0.017 |
| HDL-C · 3 years | difference 0.09 mmol/L | P = 0.018 |
| TG · 3 years | difference 16% | P = 0.044 |
| Total cholesterol · 5 years | difference 0.25 mmol/L | P = 0.027 |
| LDL-C · 5 years | difference 0.27 mmol/L | P = 0.003 |
Original publication
Effect of a high‐protein and low‐glycaemic index diet during pregnancy in women with overweight or obesity on offspring metabolic health—A randomized controlled trial. Pediatr Obes. Published 2 December 2024. doi:10.
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