Effect modification of the association between temperature variability and hospitalization for cardiovascular disease by comorbid diabetes mellitus: A nationwide time-stratified case-crossover analysis
Authors' conclusion
Comorbid diabetes may increase susceptibility to TV in relation to acute cardiovascular disease hospitalization.
Study context
- Population
- Nationwide hospitalizations for CVD in Japan, 2011–2018
- Participants
- 3,844,910 hospitalizations
- Comparison
- Cardiovascular hospitalization risk per 1 °C increase in temperature variability (TV), with vs without comorbid diabetes
- Outcome
- Cardiovascular hospitalization associated with short-term exposure to TV (SD of daily minimum and maximum temperatures within 0-7 lag days), stratified by comorbid diabetes
Methodological detailsnationwide, two-stage, adjusted for temperature and relative humidity
- Nationwide
- Two-stage
- Adjusted for temperature and relative humidity
Main finding
As reported in the abstract
HF admission risk per 1 °C increase in TV
Further findings
Cardiovascular admission risk per 1 °C increase in TV, overall
- Increase in risk of cardiovascular admission per 1 °C increase in TV
- 0.44% (95% CI: 0.22%, 0.65%)
Original publication
Effect modification of the association between temperature variability and hospitalization for cardiovascular disease by comorbid diabetes mellitus: A nationwide time-stratified case-crossover analysis. Diabetes Res Clin Pract. Published 3 June 2023. doi:10.
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