Effect of combined aerobic–resistance training and subsequent detraining on brain‐derived neurotrophic factor (BDNF) and depression in women with type 2 diabetes mellitus: A randomized controlled trial
Primary result · BDI scoreResult — go to the resultEstimate −17.17 CI −20.29 to −14.05Authors' conclusion
It may be concluded that exercise training improves depression that is likely to be explained by increased BDNF concentration in TD2. In spite of decreased BDNF concentration following an 8-week detraining, depression score was maintained.
Study context
- Population
- Women with T2D (age 60.6 ± 6.3; Body mass index (BMI) 30.2 ± 1.3 kg/m²; HbA1c 8.09 ± 0.73%)
- Participants
- 34 women
- Comparison
- 12-week combined aerobic-resistance training followed by 8-week detraining vs control
- Primary endpoint
- Beck Depression Inventory (BDI) score
Methodological detailsData analysed by linear mixed model at p < 0.05
- Data analysed by linear mixed model at p < 0.05
Primary result
BDI score · After 12 weeks of training and 8 weeks of detraining
Estimate
−17.17
CI −20.29 to −14.05
P = 0.001
As reported in the abstract
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| BDNF · After 12 weeks of training and 8 weeks of detraining | 0.08 (95% CI 0.07–0.10) | P = 0.001 |
| FPG · After 12 weeks of training and 8 weeks of detraining | −45.41 (CI −50.83 to −39.98) | P = 0.001 |
| Insulin · After 12 weeks of training and 8 weeks of detraining | −6.47 (CI −7.04 to −5.9) | P = 0.001 |
| HOMA-IR · After 12 weeks of training and 8 weeks of detraining | −3.76 (CI −4.07 to −3.45) | P = 0.001 |
Mediation of exercise-induced improvement of depression by BDNF
- BDNF seems to have a mediating role in exercise-induced improvement of depression (multiple mediation analysis)
- P = 0.04
Beck Depression Inventory (BDI) score after detraining · After 8-week detraining
- BDI score remained unchanged after detraining; significant change vs before the start of training
- P = 0.001
Original publication
Effect of combined aerobic–resistance training and subsequent detraining on brain‐derived neurotrophic factor (BDNF) and depression in women with type 2 diabetes mellitus: A randomized controlled trial. Diabet Med. Published 28 July 2023. doi:10.
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