Associations of Glucose Metabolism Status with Brain Macrostructure and Microstructure: Findings from the UK Biobank
Authors' conclusion
These findings suggest that interventions for hyperglycemia at an earlier stage may help protect brain health.
Study context
- Population
- UK Biobank participants with brain imaging
- Participants
- 29,251 participants
- Exposure
- Prediabetes, T2D with HbA1c <7% and T2D with HbA1c ≥7% vs normal glucose metabolism (NGM)
- Outcome
- Brain macro- and microstructure
Methodological detailsUK Biobank, multivariable linear regression
- UK Biobank
- Multivariable linear regression
Main finding
As reported in the abstract
Prediabetes: lower fractional anisotropy (FA) in commissural fibers, β
−0.04 (−0.08, −0.003) (95% CI)
Observational data: associations, not effects.
Original publication
Associations of Glucose Metabolism Status with Brain Macrostructure and Microstructure: Findings from the UK Biobank. J Clin Endocrinol Metab. Published 27 July 2023. doi:10.
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