Early‐pregnancy per‐ and polyfluoroalkyl substances and maternal post‐pregnancy weight trajectory
Authors' conclusion
Select PFAS, assessed in pregnancy, may affect maternal weight trajectories spanning 17 years after pregnancy, especially for older-aged individuals.
Study context
- Population
- Project Viva participants with early-pregnancy plasma concentrations of eight PFAS; weight measured at 6 months and 3, 7 and 12 years after pregnancy and self-reported annually up to 17 years
- Participants
- 1,106 participants
- Exposure
- Early-pregnancy plasma PFAS concentrations
- Outcome
- Maternal post-pregnancy weight trajectory parameters (Superimposition by Translation and Rotation model)
- Follow-up
- Up to 17 years after pregnancy
Methodological detailsProject Viva
- Project Viva
Main finding
As reported in the abstract
Weight trajectory magnitude
Perfluorooctane sulfonate (PFOS), linear regression, per doubling of PFOS
0.8 kg
95% CI 0.1 to 1.4
PFOS, Bayesian kernel machine regression (BKMR), per increase from 25th to 75th percentile
2.6 kg
95% CI 1.4 to 3.8
Perfluorononanoate, BKMR
−2.0 kg
95% CI −2.9 to −1.1
Observational data: associations, not effects.
Further findings
Weight trajectory velocity, stratified by age
- Older-aged participants had more pronounced positive associations of PFOS, perfluorooctanoate and 2-(N-ethyl-perfluorooctane sulfonamido) acetate with weight trajectory velocity
- Stratified linear regression
Original publication
Early‐pregnancy per‐ and polyfluoroalkyl substances and maternal post‐pregnancy weight trajectory. Obesity (Silver Spring). Published 12 March 2025. doi:10.
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