Endothelial cell alterations in capillaries of adipose tissue from patients affected by lipedema
Authors' conclusion
Our data support the idea that cell alterations happen in the early stages of adipocyte development (endothelium/pericyte) in the adipose organ of women affected by lipedema.
Study context
- Population
- Lean patients with lipedema stage 1 to 2, compared with patients with obesity and lean patients
- Participants
- 10 / 10 / 12
- Comparison
- Lipedema adipose tissue (affected and nonaffected areas) vs tissue from patients with obesity and lean patients
- Lipedeman = 10
- Obesityn = 10reference
- Leann = 12reference
- Outcome
- Adipose tissue alterations in lipedema
Main finding
As reported in the abstract
- Capillary wall thickening
- p ≤ 0.0001
- Endothelial and pericyte hyperplasia
- p = 0.03 and p = 0.004
- Larger (hypertrophic) adipocytes in affected areas vs obesity and lean
- P ≤ 0.0001
- Larger (hypertrophic) adipocytes in nonaffected areas vs obesity and lean
- p = 0.0003
- Massive calcium crystal deposition in adipocyte cytoplasm (Von Kossa staining)
- p = 0.023
- More abundant CD68 immunoreactive macrophages in affected areas
- p = 0.005
- Macrophage number similar to fat from patients with obesity
- p = 0.17
Original publication
Endothelial cell alterations in capillaries of adipose tissue from patients affected by lipedema. Obesity (Silver Spring). Published 12 March 2025. doi:10.
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