Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes
Primary result · Multivariable-adjusted CVD risk per decade earlier age at hypertension diagnosisResult — go to the resultHazard ratio 1.11 CI 1.03–1.21Authors' conclusion
Women with type 2 diabetes and early-onset hypertension may represent a higher-risk subpopulation that not only contributes to the excess in diabetes-related CVD risk for women but may benefit from intensive BP control.
Study context
- Population
- Adults with T2D (49% women), by age at hypertension diagnosis49% women
- Participants
- 3,792 adults
- Comparison
- Intensive vs standard BP control, by age at hypertension diagnosis, in women and men
- Primary endpoint
- Incident cardiovascular disease (CVD) events
Methodological detailssex-specific analysis, multivariable-adjusted
- Sex-specific analysis
- Multivariable-adjusted
Primary result
As reported in the abstract
Multivariable-adjusted CVD risk per decade earlier age at hypertension diagnosis
Hazard ratio
1.11
CI 1.03–1.21
P = 0.006
Per decade earlier age at hypertension diagnosis
HR 1.11 (CI 1.03–1.21); P = 0.006
Per decade earlier age at hypertension diagnosis, as printed
Further findings
| Outcome | P value |
|---|---|
| Attenuation of excess CVD risk of early-diagnosed hypertension with intensive vs standard therapy, womenExcess risk attenuated in women | P = 0.036 |
| Attenuation of excess CVD risk of early-diagnosed hypertension with intensive vs standard therapy, menNot attenuated in men | P = 0.76 |
Original publication
Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes. Diabetes Care. Published 24 April 2024. doi:10.
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