Associations of 24 h time-use compositions of sitting, standing, physical activity and sleeping with optimal cardiometabolic risk and glycaemic control: The Maastricht Study
Authors' conclusion
Shorter sitting time and more time spent standing, undergoing physical activity and sleeping are associated with preferable cardiometabolic health. The substitutions of behavioural time use were significantly stronger in their associations with glycaemic control in those with type 2 diabetes compared with those with normoglycaemic metabolism, especially when sitting time was balanced with greater physical activity.
Study context
- Population
- Adults aged 40–75 years in The Maastricht Study (48.7% female; mean age 60.1 [SD = 8.1] years; n=684 with T2D)
- Participants
- 2,388 adults
- Outcome
- 24 h time-use compositions (sitting, standing, LPA, MVPA, sleeping) associated with optimal outcome (top 5%) for waist circumference, FPG, 2 h plasma glucose, HbA1c, Matsuda index (z scores) and clustered cardiometabolic risk score
Methodological detailscompositional data analysis, isotemporal substitution, thigh-worn activPAL accelerometry, Analyses adjusted for demographics, smoking, dietary intake and diabetes status
- Compositional data analysis
- Isotemporal substitution
- Thigh-worn activPAL accelerometry
- Analyses adjusted for demographics, smoking, dietary intake and diabetes status
Main finding
As reported in the abstract
Mean (range) optimal 24 h time-use composition, considering all outcomes
- Optimal sitting
- 6 h (range 5 h 40 min-7 h 10 min)
- Optimal standing
- 5 h 10 min (4 h 10 min-6 h 10 min)
- Optimal LPA
- 2 h 10 min (2 h-2 h 20 min)
- Optimal MVPA
- 2 h 10 min (1 h 40 min-2 h 20 min)
- Optimal sleeping
- 8 h 20 min (7 h 30 min-9 h)
Observational data: associations, not effects.
Further findings
Interaction by diabetes status
- Associations stronger in T2D, with larger estimated benefits for waist circumference, fasting plasma glucose (FPG) and HbA1c when sitting replaced by LPA or MVPA vs overall sample
- P < 0.05 for interactions
Original publication
Associations of 24 h time-use compositions of sitting, standing, physical activity and sleeping with optimal cardiometabolic risk and glycaemic control: The Maastricht Study. Diabetologia. Published 24 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →