Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes
Authors' conclusion
The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.
Study context
- Population
- People with T2D
- Participants
- 49,230 people
- Outcome
- Incident CVD
Methodological detailsmultiancestry, time-to-event
- Multiancestry
- Time-to-event
Main finding
As reported in the abstract
Novel genetic loci for incident CVD
Incident cardiovascular disease (CVD) events
8,956
event rate 18.2%
rs147138607 (near CACNA1E/ZNF648), HR
1.23
P = 3.6 × 10-9
rs77142250 (near HS3ST1), HR
1.89
P = 9.9 × 10-9
rs335407 (near TFB1M/NOX3), HR
1.25
P = 1.5 × 10-8
Further findings
- Known coronary artery disease (CAD) loci associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204)
- 5 of 204
- Standardized polygenic score of the 204 variants, HR
- 1.14 (P = 1.0 × 10-16)
Original publication
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. Diabetes Care. Published 23 April 2024. doi:10.
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