Cross‐sectional, case‐control and longitudinal associations between exposure to glucagon‐like peptide‐1 receptor agonists and the dispensing of antidepressants
Main finding · Dispensed any antidepressant (cross-sectional)Result — go to the resultOdds ratio 1.44 99% CI 1.38–1.50Authors' conclusion
Individuals exposed to GLP-1 receptor agonists are at greater risk of being dispensed antidepressants. The possible impact of GLP-1 receptor agonists on the mood of consumers requires ongoing vigilance and further research.
Study context
- Population
- Individuals in the 10% random sample of Australian Pharmaceutical Benefits Scheme data, 2012–2022
- Participants
- 1,746,391 individuals
- Comparison
- Dispensing of GLP-1 RA vs no GLP-1 RA
- Outcome
- OR and HR of being dispensed any antidepressant
Methodological details10% random sample of Australian Pharmaceutical Benefits Scheme (PBS) data, adjusted for demographic measures and dispensing of CVD or anxiety/insomnia medicines, two-sided tests at 1% level of significance
- 10% random sample of Australian PBS data
- Adjusted for demographic measures and dispensing of CVD or anxiety/insomnia medicines
- Two-sided tests at 1% level of significance
Main finding
Dispensed any antidepressant (cross-sectional) · 2022
Odds ratio
1.44
99% CI 1.38–1.50
Events by group
GLP-1 receptor agonist
8495
events
As reported in the abstract
Observational data: associations, not effects.
Further findings
Antidepressant dispensing in 2022 after GLP-1 receptor agonist dispensing 2012–2021 (case-control)
| Values | OR (99% CI) | ||
|---|---|---|---|
| GLP-1 receptor agonist | GLP-1 receptor agonist 8083 events · dispensed a GLP-1 receptor agonist 2012–2021 24 103 | 1.52 (1.46–1.59) | |
| 0.512Odds ratio (log scale) |
Antidepressant dispensing 2013–2022 after GLP-1 receptor agonist dispensing (2012 cohort)
| HR (99% CI) | ||
|---|---|---|
| GLP-1 receptor agonist | 1.19 (1.12–1.27) | |
| 0.512Hazard ratio (log scale) |
- Antidepressant dispensing 2013–2022 after GLP-1 receptor agonist dispensing (2012 cohort): 2012 cohort: 1 213 316 individuals not dispensed antidepressants that year
Analyses restricting time of exposure
- Associations confirmed for all PBS-listed GLP-1 receptor agonists
Original publication
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