DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38 123 UK Biobank participants
Authors' conclusion
These findings suggest that DXA-derived hip shape is associated with hip fracture risk independently of BMD and GMs.
Study context
- Population
- UK Biobank participants with left hip DXA; mean age 63.7 yr, 52% female
- Participants
- 38,123 participants
- Exposure
- Hip shape modes vs hip fracture risk
- Outcome
- First incident hospital diagnosed hip fracture
- Follow-up
- Mean 5 yr
Methodological detailslongitudinal, statistical shape modeling of DXA images, Cox proportional hazard models, Bonferroni adjusted p-value threshold (p < .004)
- Longitudinal
- Statistical shape modeling of DXA images
- Cox proportional hazard models
- Bonferroni adjusted p-value threshold (p < .004)
Main finding
As reported in the abstract
Hip fracture risk per HSM2 (narrower FNW, higher neck shaft angle, reduced acetabular coverage)
Hip fracture with HSM2, HR (95% CI 1.11-1.58), p: 1.47 × 10-3
1.32
Hip fracture with HSM2 after full adjustment (age, sex, height, weight, BMD, FN width (FNW), hip axis length (HAL), femoral head diameter (FHD)), HR (1.09-1.55), p 3.27 × 10-3
1.30
Observational data: associations, not effects.
Further findings
Incident hip fracture · mean follow-up 5 yr
- Participants with subsequent hip fracture
- 133 (0.35%)
Original publication
DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38 123 UK Biobank participants. J Bone Miner Res. Published 20 November 2025. doi:10.
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