drCORRECT: An Algorithm for the Preventive Administration of Postprandial Corrective Insulin Boluses in Type 1 Diabetes Management
Authors' conclusion
The proposed drCORRECT algorithm allows preventive actions thanks to the personalized timing configuration and the introduction of the innovative DR-based CIB threshold, proving to be a valid alternative to the available heuristic literature methods.
Study context
- Population
- T1D; 49 continuous glucose monitoring (CGM) daily traces recorded in free-living conditions
- Participants
- 49 CGM daily traces
- Exposure
- drCORRECT vs heuristic CIB formulas
- Outcome
- Time in hyperglycemia
Methodological detailsdigital twin-based (ReplayBG), free-living CGM data
- Digital twin-based (ReplayBG)
- Free-living CGM data
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | drCORRECT | ZI |
|---|---|---|
| Daily injected insulin | 5.97 (interval [3.80, 8.06]) U | 7.5 (interval [5.21, 10.34]) U |
| Glycemia risk index | 38.78 (interval [26.58, 55.39]) | 40.78 (interval [27.95, 70.30]) |
Daily injected insulin
- Significantly reduced with drCORRECT vs ZI
Glycemia risk index
- Significantly reduced with drCORRECT vs ZI
Safety
%
| Outcome | drCORRECT | ZI |
|---|---|---|
| Time in hypoglycemia | 0.00 (interval [0.00, 1.74]) | 0.00 (interval [0.00, 10.23]) |
Time in hypoglycemia
- Significantly reduced with drCORRECT vs ZI, overall a safer strategy
Original publication
drCORRECT: An Algorithm for the Preventive Administration of Postprandial Corrective Insulin Boluses in Type 1 Diabetes Management. J Diabetes Sci Technol. Published 29 December 2023. doi:10.
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