DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk
Authors' conclusion
Results indicate that the maternal protective effect conferred through exposure to T1D in utero may operate through changes to DNA methylation that have functional downstream consequences.
Study context
- Population
- Children from the Diabetes Autoimmunity Study in the Young; 12 DLGAP2 region CpGs
- Participants
- 87 vs 87
- Comparison
- Methylation near DLGAP2 as mediator of T1D family history and T1D risk
- T1D casesn = 87
- Controlsn = 87reference
- Outcome
- Mediation of the association between T1D family history and T1D risk by methylation near DLGAP2
Methodological detailscausal mediation analysis, adjusted for HLA DR3/4 genotype
- Causal mediation analysis
- Adjusted for HLA DR3/4 genotype
Main finding
As reported in the abstract
Mediation via methylation at cg00565786: affected mother vs no family history
Pure natural indirect effect, OR
1.98
95% CI 1.06–3.71
Total natural direct effect (nonsignificant), OR
1.65
95% CI 0.16–16.62
Significant interaction between T1D family history and methylation on T1D risk, CpGs
8 of the 12
Observational data: associations, not effects.
Further findings
Methylation in DLGAP2 region and expression of nearby genes
- Associated with gene expression of DLGAP2, ARHGEF10, ZNF596 and ERICH1
- P < 0:05
Original publication
DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk. Pediatr Diabetes. Published 11 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →