Distinct maternal metabolites are associated with obesity and glucose-insulin axis in the first trimester of pregnancy
Authors' conclusion
We conclude that the metabolome of pregnant women with overweight/obesity is already altered early in pregnancy because of associated changes of C-peptide. Changes of palmitoleoyl ethanolamide concentration in pregnant women with obesity-associated hyperinsulinemia may reflect dysfunctional endocannabinoid-like signalling.
Study context
- Population
- Pregnant women, first trimester (gestational weeks 4+0–11+6); non-smoking women by serum cotinine included in further analysis111 non-smoking analysed
- Participants
- 181 women
- Outcome
- Maternal serum metabolites associated with BMI, leptin, glucose, C-peptide and/or ISHOMA
- Follow-up
- Gestational weeks 4+0-11+6
Methodological detailsuntargeted metabolomics (HPLC-MS/MS), univariable and multivariable regression, machine learning, network analysis
- Untargeted metabolomics (HPLC-MS/MS)
- Univariable and multivariable regression
- Machine learning
- Network analysis
Main finding
As reported in the abstract
- Serum features detected
- 2449
- Features annotated
- 277
- Metabolites associated with at least one exposure (body mass index (BMI), leptin, glucose, C-peptide, ISHOMA)
- 15
- Palmitoleoyl ethanolamine (POEA) associated with C-peptide in all analyses
- 95% CI: 0.10-0.34; effect size: 21%; p < 0.001
- N-acetyl-L-alanine associated with C-peptide in all analyses
- 95% CI: 0.04-0.10; effect size: 7%; p < 0.001
Observational data: associations, not effects.
Further findings
Network analysis: features correlating with POEA and N-acetyl-L-alanine and associated with C-peptide
- Amino acids or dipeptides
- n = 9, 35%
- Lipids
- n = 7, 27%
Original publication
Distinct maternal metabolites are associated with obesity and glucose-insulin axis in the first trimester of pregnancy. Int J Obes (Lond). Published 7 April 2023. doi:10.
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