Distinct functional connectivity phenotypes in preadolescent children with binge eating disorder by BMI status
Authors' conclusion
Our findings support that FC alterations between the reward network and the default mode network may be specifically impacted by the presence of BED as opposed to weight status.
Study context
- Population
- Preadolescent children with and without binge eating disorder (BED) from the Adolescent Brain Cognitive Development (ABCD) Study
- Exposure
- Children with BED with high BMI vs BED with low BMI, and children without BED
- Outcome
- Functional connectivity patterns in inhibitory control and reward networks
Methodological detailsresting-state functional connectivity, seed-to-voxel analyses
- Resting-state functional connectivity
- Seed-to-voxel analyses
Main finding
As reported in the abstract
- BED characterized by reduced connectivity between the reward network and regions in the default mode network, irrespective of weight status
- Participants with BED presented hypoconnectivity in fronto-amygdalar circuits
Observational data: associations, not effects.
Original publication
Distinct functional connectivity phenotypes in preadolescent children with binge eating disorder by BMI status. Obesity (Silver Spring). Published 10 October 2024. doi:10.
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