Differentiated Thyroid Cancers in Young Adults Versus Children: Clinical Characteristics and 10-year Follow-up Outcomes
Authors' conclusion
Young adult DTCs behave less aggressively compared with their pediatric counterparts with excellent long-term outcomes. Appropriate initial and dynamic risk stratification can help optimize treatment decisions and follow-up strategies.
Study context
- Population
- Pediatric (≤18 years) and young adult (19–39 years) patients with differentiated thyroid cancer (DTC), 1971 to 2016
- Participants
- 1,803 participants
- Exposure
- Young adults vs children with DTC
- Young adultn = 1,627
- Pediatricn = 176reference
- Outcome
- Recurrent/persistent disease
- Follow-up
- Median 10.7 years
Main finding
As reported in the abstract
P = 0.012
Observational data: associations, not effects.
Further findings
10-year DFS probability
P = 0.007
Incomplete response · 2 years posttreatment
P < 0.001
Adverse baseline features
- Extrathyroidal extension more frequent in pediatric patients
- P = 0.040
- Nodal and distant metastases and ATA high-risk disease more frequent in pediatric patients
- P < 0.001 each
Predictors of worse DFS in young adults
- ATA high-risk disease and incomplete response at 2 years independently predicted significantly worse DFS
- P < 0.001 each
Original publication
Differentiated Thyroid Cancers in Young Adults Versus Children: Clinical Characteristics and 10-year Follow-up Outcomes. J Clin Endocrinol Metab. Published 7 June 2023. doi:10.
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