Outcomes of American Thyroid Association (ATA) Low-Risk Pediatric Thyroid Cancer Patients Not Treated With Radioactive Iodine Therapy
Authors' conclusion
Withholding RAIT for pediatric patients with ATA low-risk DTC avoids exposure to radiation and does not have a negative impact on remission rates. Dynamic risk stratification at 1-year after initial treatment is a suitable time point to assess the impact of withholding RAIT for these patients.
Study context
- Population
- Patients <19 years old with ATA low-risk differentiated thyroid cancer (DTC) treated with total thyroidectomy, 2010–2020ATA low-risk DTC
- Participants
- 95 patients
- Exposure
- RAI therapy vs no RAI therapy in ATA low-risk pediatric DTC
- Radioactive iodine therapy (RAIT)n = 50
- No RAITn = 45reference
- Outcome
- Remission rate
- Follow-up
- 1 year
Methodological detailsmedical record review, multivariate logistic regression
- Medical record review
- Multivariate logistic regression
Main finding
As reported in the abstract
Remission
Observational data: associations, not effects.
Further findings
Remission with longer surveillance
Median follow-up
Range RAIT 0.9-10.9 · No RAIT 0.9-9.3
RAIT use before vs after 2015
- RAIT used in 82% of patients before 2015 vs 33% after 2015
- P < 0.01
Risk factors for persistent or indeterminate disease
- No risk factors found, including RAIT administration, N1a disease and surgery after 2015
Original publication
Outcomes of ATA Low-Risk Pediatric Thyroid Cancer Patients Not Treated With Radioactive Iodine Therapy. J Clin Endocrinol Metab. Published 2 June 2023. doi:10.
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