Male Sex Is Not a Risk Factor for Prognosis in Postoperative Thyroid Cancer Patients: A Propensity Score Matching Study
Authors' conclusion
After the reduction of selection bias by PSM, male sex was no longer a risk factor for prognosis after 131I treatment of differentiated thyroid cancer. In addition, high T stage (T3 + T4 stage), M1 stage, sTg ≥10.15 ng/mL, and 131I dose ≥260 mCi were risk factors for poor prognosis.
Study context
- Population
- Postoperative DTC patients who received 131I treatment, April 2016 to October 2021; aged 43 (IQR: 34, 54) years
- Participants
- 1,948 patients
- Exposure
- Male vs female sex
- Malen = 645
- Femalen = 1,303reference
- Outcome
- Poor prognosis after 131I treatment
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
Poor prognosis
- Before propensity score matching (PSM), proportion with poor prognosis significantly higher in male than female patients
- After PSM, no difference in proportion with poor prognosis between male and female
- Multivariate logistic regression: male sex a risk factor for poor prognosis before PSM, no longer after PSM
- Propensity-score matched
Observational data: associations, not effects.
Further findings
Other risk factors for poor prognosis (multivariate logistic regression)
- Before PSM: high T stage, N1b stage, M1 stage, high stimulated thyroglobulin (sTg) level and high 131I dose were risk factors
- After PSM: high T stage, M1 stage, high sTg level and 131I dose were still risk factors
Original publication
Male Sex Is Not a Risk Factor for Prognosis in Postoperative Thyroid Cancer Patients: A Propensity Score Matching Study. J Clin Endocrinol Metab. Published 2 June 2023. doi:10.
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