Diagnostic Efficacy of FNA-Tg in Differentiated Thyroid Carcinoma (DTC) Cervical Lymph Node (LN) Metastasis and its Impact Factors: A Large Retrospective Study
Authors' conclusion
The best cutoff value of FNA-Tg was 25.17 μg/L in diagnosing DTC cervical LN metastasis. FNA-Tg highly correlated with FNA-TgAb, but FNA-TgAb had no influence on the diagnostic efficacy of FNA-Tg.
Study context
- Population
- Suspicious cervical LNs from patients with DTC treated at West China Hospital, October 2019 to August 2021
- Participants
- 1,106 suspicious LNs
- Comparison
- FNA-Tg for diagnosis of DTC cervical LN metastasis
- Outcome
- Best cutoff of FNA-Tg for diagnosing DTC cervical LN metastasis (ROC curves)
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
Diagnostic performance of FNA-Tg at best cutoff 25.17 μg/L
| Test or model | Value | AUC | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|---|
| FNA-Tg | best cutoff 25.17 μg/L | 0.944 | 0.847 | 0.978 | 0.982 | 0.819 | 0.902 |
FNA-Tg
Valuebest cutoff 25.17 μg/L
AUC0.944
Sensitivity0.847
Specificity0.978
PPV0.982
NPV0.819
Accuracy0.902
Further findings
FNA-Tg as independent risk factor for cervical LN metastasis, nonsurgery group (adjusted for age, LN short diameter)
| OR (95% CI) | ||
|---|---|---|
| FNA-Tg | 1.048 (1.032–1.065) | |
| 0.512Odds ratio (log scale) |
FNA-Tg as independent risk factor for cervical LN metastasis, surgery group (adjusted for serum TSH, serum Tg, LN long and short diameter)
| OR (95% CI) | ||
|---|---|---|
| FNA-Tg | 1.019 (1.006–1.033) | |
| 0.512Odds ratio (log scale) |
Correlation of FNA-Tg with FNA-TgAb
- Spearman correlation coefficient
- 0.559
- P
- P < 0.01
- FNA-TgAb positivity did not undermine the diagnostic efficacy of FNA-Tg
Original publication
Diagnostic Efficacy of FNA-Tg in DTC Cervical LN Metastasis and its Impact Factors: A Large Retrospective Study. J Clin Endocrinol Metab. Published 6 June 2023. doi:10.
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