The diagnostic value of GICA used for intraoperative lymph node FNA-Tg measurement to evaluate thyroid cancer metastases
Authors' conclusion
GICA is a promising method for intraoperative FNA-Tg measurement and has high value in predicting LNM. It may be a novel alternative or supplementary method to frozen section or ECLIA.
Study context
- Population
- Papillary thyroid carcinoma (PTC) patients undergoing cervical lymph node (LN) dissection; LNs from central and lateral compartments
- Participants
- 51 patients150 LNs
- Comparison
- Intraoperative FNA-Tg by GICA vs electrochemiluminescence immunoassay (ECLIA) and frozen sections
- Outcome
- Diagnostic performance (ROC AUC, cutoff, sensitivity, specificity, accuracy) for LNM
Methodological detailsprospective
- Prospective
Performance
As reported in the abstract
FNA-Tg cutoff to predict LNM
| Test or model | Value | Cutoff at 3 min | Cutoff at 10 min | Cutoff at 15 min |
|---|---|---|---|---|
| ECLIA | 110.83 ng/mL | |||
| GICA | 13.19 ng/mL | 38.69 ng/mL | 77.17 ng/mL |
Value
ECLIA110.83 ng/mL
GICA— not stated in the abstract
Cutoff at 3 min
ECLIA— not stated in the abstract
GICA13.19 ng/mL
Cutoff at 10 min
ECLIA— not stated in the abstract
GICA38.69 ng/mL
Cutoff at 15 min
ECLIA— not stated in the abstract
GICA77.17 ng/mL
Further findings
Diagnostic performance by compartment and TgAb subgroup
- GICA and ECLIA showed no significant difference for central and lateral compartments or TgAb-positive vs TgAb-negative subgroups
Original publication
The diagnostic value of GICA used for intraoperative lymph node FNA-Tg measurement to evaluate thyroid cancer metastases. Eur Thyroid J. Published 29 January 2024. doi:10.
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