Differential Diagnosis of Post Pancreatitis Diabetes Mellitus Based on Pancreatic and Gut Hormone Characteristics
An erratum to this article was published (J Clin Endocrinol Metab, 12 Jul 2024 ↗)
Authors' conclusion
Along with the continuum from acute to chronic pancreatitis, the pathological mechanism of PPDM changes from insulin resistance to insulin deficiency. Insufficient PYY secretion is a promising diagnostic marker for distinguishing PPDM from type 1 and type 2 diabetes. Absent ghrelin secretion to MMTT may help identify PPDM-C.
Study context
- Population
- Participants with PPDM-A, PPDM-C, T1D, T2D and normal controls
- Exposure
- PPDM-A and PPDM-C vs T1D, T2D and normal controls
- Outcome
- Fasting and postprandial hormone responses to mixed meal tolerance test (MMTT)
Methodological detailsmixed meal tolerance test
- Mixed meal tolerance test
Main finding
As reported in the abstract
- PPDM-A vs normal controls (NCs): increased C-peptide, insulin, glucagon and pancreatic polypeptide (PP); decreased ghrelin, gastric inhibitory peptide (GIP) and PYY
- PPDM-C vs NCs: secretion insufficiency of C-peptide, insulin, ghrelin and PYY; higher postprandial glucagon and PP
- Fasting and postprandial ghrelin in PPDM-C significantly lower than other diabetes groups
- PYY responses markedly reduced in PPDM-A and PPDM-C
- Insulin sensitivity decreased in PPDM-A; insulin secretion decreased in PPDM-C
Observational data: associations, not effects.
Original publication
Differential Diagnosis of Post Pancreatitis Diabetes Mellitus Based on Pancreatic and Gut Hormone Characteristics. J Clin Endocrinol Metab. Published 12 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →