Pituitary & hypothalamus

Diagnostic criteria for the hypothalamic syndrome in childhood

Eur J EndocrinolPublished Diagnostic criteria development study with retrospective cohort testing

Authors' conclusion

The here proposed diagnostic criteria for hypothalamic dysfunction and score for presence of HS may be used for care purposes and to aid in early recognition. Also it will be useful for research or registration purposes.

Study context

Population
Patients at risk for hypothalamic dysfunction in childhood
Participants
120 patients
Outcome
HS by new hypothalamic score
Methodological detailsCriteria subdivided into hyperphagia, hypophagia, BMI, behavioral problems, sleep disorders, temperature regulation disorders, pituitary dysfunction, radiological hypothalamic assessment, and presence/suspicion of hypothalamic genetic syndrome
  • Criteria subdivided into hyperphagia, hypophagia, BMI, behavioral problems, sleep disorders, temperature regulation disorders, pituitary dysfunction, radiological hypothalamic assessment, and presence/suspicion of hypothalamic genetic syndrome

Performance

As reported in the abstract

Scored as having hypothalamic syndrome (HS)
52.5%
Of these, pituitary dysfunction
76.7%
Of these, hyperphagia
32.5%
Of these, sleep disorders
40%
Of these, temperature dysregulation
14.2%

Original publication

Diagnostic criteria for the hypothalamic syndrome in childhood. Eur J Endocrinol. Published 3 February 2023. doi:10.1093/ejendo/lvad009

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