Irreversible Alterations of Susceptibility in Cushing's Disease: A Longitudinal Quantitative Susceptibility Mapping (QSM) Study
Authors' conclusion
Chronic exposure to hypercortisolism may be related to susceptibility alterations and significantly correlated with altered brain volumes and clinical features. in CD patients. The decrease of susceptibility might suggest the involvement of the calcium deregulation in these alterations.
Study context
- Population
- Patients with Cushing's disease (CD) and healthy controls
- Participants
- 24 vs 24
- Exposure
- CD patients before and after resolution of hypercortisolism vs healthy controls
- CDn = 24
- Healthy controlsn = 24reference
- Outcome
- Longitudinal brain susceptibility changes on QSM before and after resolution of hypercortisolism
- Follow-up
- Before and after curative operation
Methodological detailsbefore and after curative operation, healthy controls
- Before and after curative operation
- Healthy controls
Main finding
As reported in the abstract
Brain susceptibility (QSM) · after resolution of hypercortisolism
- Irreversibly altered susceptibility values in the anterior cingulate cortex, frontal lobe, caudate and red nucleus after resolution of hypercortisolism
- Alterations significantly correlated with changes in gray matter/white matter volumes and clinical features
Observational data: associations, not effects.
Further findings
- Decreased susceptibility in several regions in CD patients
Original publication
Irreversible Alterations of Susceptibility in Cushing's Disease: A Longitudinal QSM Study. J Clin Endocrinol Metab. Published 1 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →