Pregnancy-related hypophysitis revisited
Authors' conclusion
PR-Hy has distinct features that delineate the disorder from non-PR-Hy. With increasing experience in diagnosis, availability of adequate replacement therapy, and improved treatment modalities, PR-Hy has lost its threat and the outcome is encouraging.
Study context
- Population
- All published cases with pregnancy-related hypophysitis (PR-Hy) and 6 own cases
- Participants
- 148 PR-Hy cases
- Exposure
- Pregnancy-related hypophysitis vs non-pregnancy autoimmune hypophysitis
- Outcome
- Distinguishing features of PR-Hy vs non-pregnancy autoimmune hypophysitis
Methodological detailsliterature review (PubMed search)
- Literature review (PubMed search)
Main finding
As reported in the abstract
Distinguishing features of PR-Hy vs non-PR-Hy
- PR-Hy vs non-PR-Hy: P < 0.0001
- PR-Hy vs non-PR-Hy: P = 0.0005
- PR-Hy vs non-PR-Hy: P < 0.0001
- PR-Hy vs non-PR-Hy: P < 0.0001
Observational data: associations, not effects.
Further findings
Treatment over time in PR-Hy
- Role of surgery decreased over time while noninvasive treatment modalities increased
Recurrence rate in PR-Hy by treatment
- After high-dose glucocorticoid therapy
- 33%
- After surgery
- 2%
- After conservative management
- 2%
Maternal and child outcome
- Recurrent PR-Hy in a subsequent pregnancy
- 2 females
- Recent literature on mother's and child's health outcome was positive
- Frequency of spontaneous preterm delivery not increased
Original publication
Pregnancy-related hypophysitis revisited. Eur J Endocrinol. Published 19 January 2023. doi:10.
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