Lupus‑Associated Hypophysitis: A Narrative Systematic Review of Clinical, Radiological and Endocrine Features
Authors' conclusion
Lupus-associated hypophysitis is a rare manifestation of SLE with heterogeneous endocrine and radiological presentations that may create diagnostic challenges.
Study context
- Population
- Patients meeting accepted systemic lupus erythematosus (SLE) criteria with hypophysitis or hypothalamic-pituitary inflammation attributed to SLE after exclusion of alternative sellar pathology
- Participants
- 11 case reports
- Outcome
- Clinical, radiological and endocrine features
Methodological detailsdescriptive synthesis, MEDLINE, Embase, Web of Science and Google Scholar searched to 10 November 2025
- Descriptive synthesis
- MEDLINE, Embase, Web of Science and Google Scholar searched to 10 November 2025
Pooled result
As reported in the abstract
Female
63%
Median age
23 years
Further pooled results
Treatment outcomes
- High-dose glucocorticoids, with or without additional immunosuppression, led to improvement in most cases
- Persistent adrenal and gonadal deficits were common
Death
- Died from severe hyponatraemia
- 1 patient
Original publication
Lupus‑Associated Hypophysitis: A Narrative Systematic Review of Clinical, Radiological and Endocrine Features. Clin Endocrinol (Oxf). Published 3 August 2026. doi:10.
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