Diabetic retinopathy related homeostatic dysregulation and its association with mortality among diabetes patients: A cohort study from NHANES
Authors' conclusion
Our study constructed the DRHD value as a measure to assess homeostatic dysregulation among individuals with type 2 diabetes. The DRHD values exhibited potential as a prognostic indicator for retinopathy and for mortality in patients affected by type 2 diabetes.
Study context
- Population
- Individuals with T2D, NHANES
- Participants
- 6,420 individuals
- Exposure
- Highest vs reference quartile of DRHD value
- Outcome
- Mortality: all-cause, cardiovascular disease (CVD) and diabetes-specific
- Follow-up
- Average of 8 years
Methodological detailsNHANES data, LASSO regression, Mahalanobis distance approach, Cox proportional hazards regression, multivariable-adjusted, Web-based DRHD value calculator developed
- NHANES data
- LASSO regression
- Mahalanobis distance approach
- Cox proportional hazards regression
- Multivariable-adjusted
- Web-based DRHD value calculator developed
Main finding
As reported in the abstract
Mortality by DRHD value
Estimate (95 % CI)
Highest quartile
HR (all-cause mortality) 2.04(1.76–2.37)
Highest quartile
HR (CVD mortality) 2.32(1.78–3.01)
Highest quartile
HR (diabetes-specific mortality) 2.29(1.72–3.04)
Observational data: associations, not effects.
Further findings
Biomarkers associated with DR for DRHD construction
- Biomarkers identified from 40 clinical parameters
- 14
Original publication
Diabetic retinopathy related homeostatic dysregulation and its association with mortality among diabetes patients: A cohort study from NHANES. Diabetes Res Clin Pract. Published 29 December 2023. doi:10.
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