Diabetes mellitus complications and their association with patient-reported outcome measures: a longitudinal study of the SwissDiab cohort
Authors' conclusion
Diabetes complications reduce quality of life, with myocardial infarction (-0.05 EQ-5D utility) in type 2 and renal failure (-19 VAS points) in type 1, with decrements smaller than previous estimates.
Study context
- Population
- Patients with T1D and T2D in the Swiss diabetes registry (2015–2022) completing ≥2 annual EQ-5D-3L questionnaires
- Participants
- 896 patients
- Exposure
- Diabetes complication severity vs quality of life, T1D and T2D
- Type 1n = 422
- Type 2n = 474
- Outcome
- Within-patient association between complication severity (aDCSI) and quality of life (EQ-5D, VAS)
Methodological detailsregistry-based, mixed-effects regression
- Registry-based
- Mixed-effects regression
Main finding
As reported in the abstract
Association of aDCSI with quality of life
- Higher adapted Diabetes Complications Severity Index (aDCSI) scores were associated with reduced quality of life in both diabetes types
- Adjusted for patient characteristics and survey time
Observational data: associations, not effects.
Further findings
| Outcome | Type 1 | Type 2 |
|---|---|---|
| EQ-5D | 0.96 | 0.88 |
| VAS | 82.1 | 75.5 |
≥1 complication at baseline
- ≥1 complication at baseline
- 83%
Other associations and change over time
- Developed complications
- 4.9%
- Women and insulin-treated patients reported lower scores
- No quality of life decrement over time was observed
Original publication
Diabetes mellitus complications and their association with patient-reported outcome measures: a longitudinal study of the SwissDiab cohort. Diabetes Res Clin Pract. Published 15 April 2026. doi:10.
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