Diabetes, glycaemic traits and cardiovascular disease in females and males: Observational and Mendelian randomisation analyses in the UK Biobank
Authors' conclusion
This study suggests that causal effects of diabetes and glycaemic traits on CVD are similar in females and males.
Study context
- Population
- UK Biobank participants
- Exposure
- Females vs males: associations of T2D and HbA1c with cardiovascular disease (CVD) outcomes
- Outcome
- Sex-specific associations of T2D and HbA1c with CVD outcomes (combined CVD, CHD, MI, stroke, ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage)
Methodological detailssex-stratified, UK Biobank
- Sex-stratified
- UK Biobank
Main finding
As reported in the abstract
Female-to-male ratio of HRs (observational)
1.11
95% CI 1.03–1.21
greater excess risk for CHD in females
Female-to-male ratio of ORs (Mendelian randomisation (MR))
0.98
95% CI 0.91–1.05
similar in females and males
Observational data: associations, not effects.
Further findings
Diabetes and stroke
- No sex differences in observational and MR analyses
MR of HbA1c, fasting glucose and fasting insulin
- MR results similar for females and males
Original publication
Diabetes, glycaemic traits and cardiovascular disease in females and males: Observational and Mendelian randomisation analyses in the UK Biobank. Diabetes Obes Metab. Published 21 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →