The influence of the glucagon‐like peptide‐1 receptor agonist, liraglutide, on dietary patterns and nutrient intakes in patients with obesity and prediabetes: A secondary analysis of a randomized controlled trial
Authors' conclusion
Overall diet quality was poor across all groups. However, the caloric restriction group significantly reduced its added sugar intake, highlighting a potential benefit nutrition counselling may have for AOM users. Future research is needed to examine the long-term impact of AOM use on dietary intake, with and without nutrition guidance, to better inform clinical recommendations.
Study context
- Population
- Adults with obesity and prediabetes; 69% female, 83% white; mean age 49.4 ± 11.3 years, mean BMI 39.5 ± 6.1 kg/m²
- Participants
- 70 adults
- Comparison
- Liraglutide vs dietitian-supported caloric restriction vs DPP-4i
- Primary endpoint
- Changes in dietary intake (macronutrients, micronutrients, diet quality, food sources) by single 24-h dietary recall
- Follow-up
- Pre- and postintervention (14 weeks)
Methodological detailsDietary intake assessed via a single 24-h dietary recall pre- and postintervention
- Dietary intake assessed via a single 24-h dietary recall pre- and postintervention
Primary result
As reported in the abstract
Change in percent calories from protein, carbohydrates and added sugar · pre- to postintervention (14 weeks)
- Significant differences across groups in change in % calories from protein, carbohydrates and added sugar; caloric restriction had greatest increase in protein and decreases in carbohydrates and added sugar
- Liraglutide vs Dipeptidyl peptidase-4 inhibitor: P = 0.037
- Liraglutide vs Dipeptidyl peptidase-4 inhibitor: P = 0.019
- Liraglutide vs Dipeptidyl peptidase-4 inhibitor: P = 0.002
- Single 24-h dietary recall pre- and postintervention
Further findings
| Outcome | P value |
|---|---|
| HEI component score for added sugar, adjusted for baseline intakeCaloric restriction vs Liraglutide · significantly improved with Caloric restriction · adjusted for baseline intake | P = 0.002 |
Meeting nutrition recommendations
- Regardless of group, participants failed to meet several of the same recommendations, incl. fruit, vegetable and dairy intake
Original publication
The influence of the glucagon‐like peptide‐1 receptor agonist, liraglutide, on dietary patterns and nutrient intakes in patients with obesity and prediabetes: A secondary analysis of a randomized controlled trial. Diabetes Obes Metab. Published 21 April 2025. doi:10.
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