Mediating role of inflammatory biomarkers in the causal effect of body composition on glycaemic traits and type 2 diabetes
Authors' conclusion
Our findings suggest that different body compositions have differential influences on glycaemic traits and type 2 diabetes through distinct inflammatory biomarkers. The findings may be helpful in tailoring management of body composition based on inflammatory biomarkers with different glycaemic statuses.
Study context
- Population
- Chinese children and adolescents aged 6–18 years with DXA body composition (observational); Mendelian randomization (MR) on summary statistics from UK Biobank, deCODE2021, MAGIC and other large consortiumsobservational cohort
- Participants
- 4,717 children
- Outcome
- Mediation by inflammatory biomarkers of body composition effects on glycaemic traits and T2D
Methodological detailsmediation analysis
- Mediation analysis
Main finding
As reported in the abstract
- Observational: Parathyroid hormone (PTH) and osteocalcin played significant roles in the association of fat mass and fat-free mass with fasting glucose, fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR)
- all p < 0.05
- MR: fat-free mass on T2D via FGF23, indirect effect OR
- 1.14 (1.01-1.28) (95% CI)
- MR: fat-free mass on T2D via adiponectin, OR
- 0.85 (0.77-0.93) (95% CI)
- MR: leptin mediating fat mass effect on fasting glucose, indirect effect β
- −0.05 (−0.07, −0.02) (95% CI)
- MR: leptin mediating fat-free mass effect on fasting glucose, β
- 0.03 (0.01, 0.04) (95% CI)
Observational data: associations, not effects.
Original publication
Mediating role of inflammatory biomarkers in the causal effect of body composition on glycaemic traits and type 2 diabetes. Diabetes Obes Metab. Published 4 September 2024. doi:10.
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