Diabetes-dependent association between metabolic score for visceral fat and chronic kidney disease: findings from a longitudinal cohort study
Authors' conclusion
Higher METS-VF was associated with increased risk of CKD development; however, it was confined to individuals with normal glucose tolerance. This suggests METS-VF may serve as an exploratory marker for stratified risk assessment for early CKD risk before the onset of glucose dysregulation, emphasizing the critical window for early metabolic intervention.
Study context
- Population
- Participants in the Korean Genome and Epidemiology Study
- Participants
- 8,092 participants
- Exposure
- Metabolic score for visceral fat (METS-VF) quartiles
- Outcome
- Incident CKD
- Follow-up
- Mean 12.8 years
Methodological detailslongitudinal, population-based
- Longitudinal
- Population-based
Main finding
As reported in the abstract
Q4 vs Q1Estimate (95% CI)P value
Incident CKD
HR (unadjusted) 2.941(2.591–3.339)
P < 0.001Multivariate adjustment
aHR 1.373(1.201–1.571)
P < 0.001- Incident chronic kidney disease (CKD) cases
- 2,202
Observational data: associations, not effects.
Further findings
Subgroups by diabetes status
- Association between METS-VF and incident CKD significant only in individuals with normoglycemia
Original publication
Diabetes-dependent association between metabolic score for visceral fat and chronic kidney disease: findings from a longitudinal cohort study. Diabetes Res Clin Pract. Published 28 April 2026. doi:10.
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