Impact of visceral fat on coronary artery disease as defined by quantitative computed tomography angiography
Authors' conclusion
These findings demonstrate progression with regard to VF and TPV, NCP volume, and LD-NCP volume. Notably, there was a progression of VF and amount of LD-NCP, which is known to be high risk for future cardiovascular events. A consistent progression may indicate the future utility of VF in CVD risk stratification.
Study context
- Population
- Consecutive asymptomatic patients; mean age 56.1 [SD 8.5] years, 84.0% male
- Participants
- 145 patients
- Exposure
- Visceral fat (VF) quartiles vs coronary plaque volume on quantitative CT angiography
- Outcome
- Relationship between presence and severity of VF and presence and severity of coronary artery plaque
Methodological detailsconsecutive asymptomatic patients
- Consecutive asymptomatic patients
Main finding
As reported in the abstract
Total plaque volume (TPV)
0.22
p = 0.0074
Calcified plaque
0.12
p = 0.62
Noncalcified plaque (NCP)
0.25
p = 0.0023
Low-density NCP (LD-NCP)
0.37
p < 0.0001
Observational data: associations, not effects.
Further findings
Median TPV by VF quartile — between Q1 and Q4 · across quartiles
P = 0.0098
Median NCP volume by VF quartile — between Q1 and Q4 · across quartiles
P = 0.0032
Median LD-NCP volume by VF quartile — between Q1 and Q4 · across quartiles
P < 0.0001
Adiposity measures, mean [SD, Q1–Q3]
- Estimated body fat
- 28.7% (9.0%, 24.1%-33.0%)
- VF
- 169.8 cm² (92.3, 102.0-219.0 cm² )
- Subcutaneous fat
- 223.6 mm² (114.2, 142.5-288.0 mm² )
Original publication
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